Bus Route 12 services Woodland to Society Hill, with stops at 50th St and Woodland Av, Civic Center Blvd and University Av, 22nd, and Locust Sts, and 3rd and Pine Sts.
 
Bus Route 21 will take you from Penn's Landing to 69th Street Terminal via Chestnut and Walnut Sts, stopping at 61st, 52nd, 40th, 30th, 17th, Broad and 8th Sts, before reaching Penn's Landing.
 
Bus Route 23 operates from Chestnut Hill to South Philadelphia via Germantown Avenue, 11th, and 12th Sts, stopping at Germantown and Bethlehem Pike (Loop), Broad and Erie, Germantown and Lehigh, 12th and Market, and Broad and Oregon.
 
Bus Route 38 travels between the Independence Mall and the Wissahickon Transportation Center, with stops at Presidential Blvd and Winding Way, 16th and Market St, and Broad and Chestnut Sts.
 
Bus Route 42 runs service from Wycombe and West Philadelphia to Penn's Landing via Spruce, Chestnut and Walnut Sts, stopping at Sherbrook Blvd and Springton Rd, 61st, 52nd, 40th, Broad and 8th Sts, before reaching Penn's Landing.

Bus Route 47 runs from Olney to South Philadelphia with stops at 5th and Godfrey Ave, 8th and Spring Garden Sts, 8th and Market Sts, and Whitman Plaza.
 
Bus Route 47m operates from South Philadelphia to 7th and Spring Garden via 9th Street, stopping at Whitman Plaza, Washington Ave, and Market St before reaching 7th and Spring Garden.

Market-Frankford Line runs service from 69th Street Terminal to the Frankford Transportation Center, stopping at a variety of locations along Market Street and Frankford Ave.

Market East Station is a stop for nearly all of SEPTA's Regional Rail Lines, including:

R1 Airport runs service from Center City to the Philadelphia International Airport, Glenside, Warminster and West Trenton (weekends only) stopping at all three Center City Stations; Market East, Suburban, and 30th Street. Other stops include, Airport Terminals E, C, D, B, and A, Eastwick, University City, Temple University, Wayne Junction, Melrose Park, Elkins Park, Jenkintown, Glenside, and Warminster.

R2 Marcus-Hook/Wilmington and Newark runs from Central Philadelphia to Wilmington and the Philadelphia International Airport, stopping at all three Center City Stations; Market East, Suburban and 30th Street Station. Other stops include Temple University, Darby, Sharon Hill, Curtis Park, Glenolden, Ridley Park, Chester, Marcus Hook, Wilmington, and Newark.

R2 Warminster runs from Central Philadelphia, Wilmington, and the Philadelphia International Airport, stopping at all three Center City Stations; Market East, Suburban, and 30th Street. Other stops include Warminster, Hatboro, Willow Grove, Crestmont, Roslyn Ardsley, Glenside, Jenkintown, Elkins Park, Melrose Park, Fern Rock, Wayne Junction, Temple University, University City, and Airport Terminal E.

R3 West Trenton operates from Center City to West Trenton and Elwyn stopping at all three Center City Stations; Market East, Suburban and 30th Street Station. Other stops include West Trenton, Yardley, Woodbourne, Langhorne, Neshaminy Falls, Trevose, Somerton, Forest Hills, Philmont, Bethayres, Meadowbrook, Rydal, Noble, Jenkintown-Wyncote, Elkins Park, Fern Rock T.C., Wayne Junction, Temple, Media, and Elwyn.

R3 Media/Elwyn runs service from Center City to Media, Elwyn, and West Trenton, stopping at all three Center City Stations; Market East, Suburban, and 30th Street. Other stops include Elwyn, Media, Moylan-Rose Valley, Wallingford, Swarthmore, Morton, Secane, Primos, Clifton-Aldan, Gladstone, Lansdowne, Fernwood, Angora, 49th Street, University City, Temple University, and West Trenton.

R5 Lansdale/Doylestown runs service from Center City to Lansdale, Doylestown, Paoli, and Thorndale, stopping at all three Center City Stations; Market East, Suburban and 30th Street Station. Other stops include Delaware Valley College Station, New Britain, Chalfont, Link Belt, Colmar, Fortuna, Lansdale, Pennbrook, North Wales, Gwynned Valley, Penllyn, Ambler, Fort Washington, Oreland, North Hills, Glenside, Jenkintown-Wyncote, Elkins Park, Melrose Park, Fern Rock T.C., Wayne Junction, North Broad, Temple, Bryn Mawr, Paoli and Thorndale.

R5 Paoli/Thorndale runs service from Center City to Paoli, Thorndale, and Doylestown stopping at all three Center City Stations; Market East, Suburban and 30th Street Station. Other stops include Overbrook, Merion, Narberth, Wynnewood, Ardmore, Bryn Mawr, Haverford, Rosemont, Villanova, Radnor, Wayne, Berwyn, Paoli, Malvern, Thorndale, Lansdale, and Doylestown.

R6 Norristown runs service from Center City to Norristown three Center City Stations; Market East, Suburban and 30th Street Station. Other stops include Elm St, Main St, the Norristown Transportation Center, Conshohocken, Spring Mill, Miquon, Ivy Ridge, Manayunk, the Wissahickon Transportation Center, East Falls, Allegheny, North Broad, Temple University, and University City.

R7 Chestnut Hill East and Trenton runs service from Center City to Chestnut Hill East and Trenton (with connecting service to New York City) stopping at all three Center City Stations; Market East, Suburban and 30th Street Station. Other stops Trenton, Levittown, Bristol, Croydon, Eddington, Cornwells Heights, Torresdale, Holmesburg, Bridesburg, North Philadelphia, Temple University, Wayne Junction, Wister, Germantown, Washington Lane, Stenton, Sedgwick, Mount Airy, Wyndmoor, Gravers, and Chestnut Hill East.
 
R8 Fox Chase and Chestnut Hill West runs service from Center City to Fox Chase and Chestnut Hill West stopping at all three Center City Stations; Market East, Suburban and 30th Street Station. Other stops Chestnut Hill West, Highland, St. Martins, Allen Lane, Carpenter, Upsal, Tulpehocken, Chelten Ave, Queen Lane, North Philadelphia, Temple University, Wayne Junction, Olney, Lawndale, Cheltenham, Ryers, and Fox Chase.