Bus Route 1 travels from Northeast Philadelphia to the Wissahickon Transportation Center, or 54th and City Ave, via Roosevelt Blvd, with stops at Byberry Industrial Park, the I.R.S., Roosevelt Blvd and Cottman Ave, Roosevelt and Tower Blvd, Roosevelt and Broad, Wissahickon Transportation Center, and 54th and City Ave.

Bus Route 44 operates from Ardmore to Independence Mall via the Schuylkill Expressway, with stops at Ardmore Station (R5), Narberth Station (R5), City Ave and Presidential Blvd, 16th and Market, and 5th St North of Market.

Bus Route 52 runs service via 52nd Street, making stops at 54th and City Ave, 52nd and Girard Ave, 52nd and Market, 52nd and Baltimore Ave, and 49th and Woodland Ave.
 
Bus Route 65 operates from Germantown to 69th Street Terminal via City Ave, with stops at 63rd St and Malvern Ave, City and Belmont Aves, Wissahickon Transportation Center, and Germantown and Chelten Aves.
 
Bus Route 121 services Gladwyne to Independence Mall via the Schuylkill Expressway, stopping at Gladwyne, Conshohocken State Rd and Bala Ave (Cynwyd Station, R6), Bala and City Ave (Bala Station, R6), 16th and Market, and 5th St North of Market.
 
Route G operates from South Philadelphia to Overbrook, with stops at Broad St and Oregon Ave, 58th St and Woodland Ave, 56th and Market Sts, and Overbrook Station (R5).

R5 Paoli/Thorndale runs service from Center City to Paoli, Thorndale, and Doylestown stopping at all three Center City Stations; Market East, Suburban and 30th Street Station. Other stops include Overbrook, Narberth, Wynnewood, Ardmore, Haverford, Bryn Mawr, Rosemont, Villanova, Radnor, St. Davids, Wayne, Strafford, Devon, Berwyn, Daylesford, Paoli, Malvern, Exton, Whitford, Downingtown, and Thorndale.
 
R6 Cynwyd runs service from Center City to Cynwyd stopping at two Center City Stations; Suburban and 30th Street. Other stops include, Cynwyd, Bala, and Wynnefield Ave.